Analyzing hematological indices and clinical associations of FLT3 mutation in acute leukemia

Objective: The purpose of this research is to examine the relationship between FLT3 mutation and hematological indices clinical correlates in patients with severe myelogenous leukemia & acute lymphoblastic leukemia. Study Design: Descriptive Study. Place Duration: Diagnostic Laboratory Liaquat university Medical health sciences jamshoro Hyderabad. January 2021 December 2021. Methods: Total 79 cases were included study. Patients provided written consent for detailed demographics self-structure questionnaire. All data was obtained from laboratory records. patients' clinico-hematologic immunophenotypic characteristics recorded, analyzed molecularly. SPSS 24.0 used analyze all data. Results: Majority 44 (55.7%) males 35 (44.3%) females. had mean age 37.21±14.59 years BMI 23.6±4.18 kg/m2. We found that 48 (60.8%) myeloid (AML) 31 (39.2%) (ALL). Frequency FLT 3 mutations AML 6 (12.5%) ALL 1 (3.2%) after polymerase chain reaction. WBC most statistically significant result connected mutation.